Andrade L A, Borges V, Ferraz H B, Azevedo-Silva S M
Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo, Escola Paulista de Medicina, Brasil.
Arq Neuropsiquiatr. 1997 Sep;55(3B):553-7. doi: 10.1590/s0004-282x1997000400006.
Botulinum toxin A is the more efficient therapy of focal dystonias and hemifacial spasm. Our experience with botulinum toxin A injections in 115 patients is reported. Marked or total improvement was achieved in all 45 patients with hemifacial spasm, in 70% of 20 patients with essential blepharospasm and in 71.4% of 14 patients with Meige's syndrome. In 65.2% of 23 patients with cervical dystonia marked but no total improvement was obtained. The worse results were seen in the 6 patients with hand dystonia (writers cramp), in whom marked improvement was obtained in just two. Mild and transient complications occurred in up to 24.4%, eyelid ptosis and eyelid weakness being the most frequent. One patient with Meige's syndrome had an aspiration pneumonia following dysphagia. Our results are in agreement with others, showing that botulinun toxin A is a useful and safe treatment for these conditions.
A型肉毒杆菌毒素是治疗局限性肌张力障碍和半面痉挛更有效的方法。本文报告了我们对115例患者进行A型肉毒杆菌毒素注射的经验。45例半面痉挛患者均有明显或完全改善，20例原发性眼睑痉挛患者中有70%改善，14例Meige综合征患者中有71.4%改善。23例颈部肌张力障碍患者中有65.2%有明显改善但未完全改善。手部肌张力障碍（书写痉挛）的6例患者效果最差，仅2例有明显改善。高达24.4%的患者出现轻微和短暂的并发症，其中眼睑下垂和眼睑无力最为常见。1例Meige综合征患者因吞咽困难发生吸入性肺炎。我们的结果与其他研究一致，表明A型肉毒杆菌毒素是治疗这些疾病的一种有效且安全的方法。
