Christoph C G, Thumala M I, Nazer J, Armanet L, Cifuentes L
Facultad de Medicina, Universidad de los Andes.
Rev Med Chil. 1998 Jan;126(1):27-31.
In man, blood groups are polymorphic genetic systems. Maternal fetal incompatibility phenomena should lead to an elimination rather than a maintenance of these polymorphisms. A possible mechanism that could explain the persistence of these polymorphisms in natural populations is a selective reproductive advantage of heterozygous individuals.
To explore the relationship between maternal heterozygosity for five blood groups and some obstetrical variables related to gestational success.
Using a case control design, to every mother giving birth to a malformed child a consecutive mother, whose offspring was normal, was assigned as control. All women were typified for ABO, Rh, Kidd, MNSs and Duffy blood groups.
Two hundred two women were studied. There was only one stillbirth, born from a heterozygous mother for all analyzed loci. Mothers that were heterozygous or homozygous for all loci had a higher frequency of malformed children. Women homozygous for all loci had a higher frequency of living offspring than the rest of the sample.
Heterozygous mothers for these genetic systems have a reproductive disadvantage.
在人类中，血型是多态性遗传系统。母胎不相容现象本应导致这些多态性的消除而非维持。一个能够解释这些多态性在自然种群中持续存在的可能机制是杂合个体具有选择性生殖优势。
探讨母亲在五种血型上的杂合性与一些与妊娠成功相关的产科变量之间的关系。
采用病例对照设计，为每一位生育畸形儿的母亲分配一位连续生育且后代正常的母亲作为对照。所有女性均进行ABO、Rh、基德、MNSs和达菲血型分型。
共研究了202名女性。仅出现一例死产，其母亲在所有分析位点均为杂合子。在所有位点均为杂合子或纯合子的母亲所生畸形儿的频率更高。在所有位点均为纯合子的女性活产后代的频率高于其余样本。
这些遗传系统的杂合子母亲具有生殖劣势。
