Pérez De Oteyza C, García Cortés A, Menéndez Martínez M A, Torres Léon J M, Pérez Aznar C, Carnicero Bujarrabal M
Servicio de Enfermedades Infecciosas, Hospital Militar Gómez Ulla, Madrid.
An Med Interna. 1998 May;15(5):255-8.
To value the effects of megestrol acetate wer the weight and the body composition (fat, lean and body water) in patients with AIDS associated cachexia, by bioelectric impedance analysis.
25 patients between 23 and 57 years of age, with confirmed HIV infection and prior weight lost of 7.96 +/- 4.6 kg in relation to their habitual weight in the previous months. All the patients were under antiretroviral therapy.
Basal determination, before the beginning of the antianorexic treatment and at the end of it, using bioelectric impedance analysis by Maltron BF 905 analyzer, calculating fat, lean and total body water in relation to weight, height, age and sex. Oral administration of 320 mg/day megestrol acetate for three consecutive months. Statistical comparation (RSIGMA and SPSS) by paired t-test of the mean weight, body mass index, fat, lean and total body water.
During the three months treatment the mean basal body weight of the patients increased 3.54 Kg (p < 0.001) at the expense of an increase of 2.24 kg in the total body lean (p < 0.01), while the increment of the body fat (1.2 kg) was not statistically significant. The total body water increased 1.48 L (p < 0.001) and the body mass index in 1.22 kg/m2 (p < 0.001).
Treatment with megestrol acetate results in a substained and very significant increase of the weight and body mass index in patients with AIDS related cachexia. This increment in weight is at the expense of body lean.
通过生物电阻抗分析评估醋酸甲地孕酮对艾滋病相关恶病质患者体重和身体成分（脂肪、瘦体重和身体水分）的影响。
25例年龄在23至57岁之间的患者，确诊为HIV感染，且与前几个月的习惯体重相比，体重先前已减轻7.96±4.6千克。所有患者均接受抗逆转录病毒治疗。
在抗厌食治疗开始前和结束时进行基础测定，使用Maltron BF 905分析仪通过生物电阻抗分析，根据体重、身高、年龄和性别计算脂肪、瘦体重和全身水分。连续三个月口服320毫克/天的醋酸甲地孕酮。通过配对t检验对平均体重、体重指数、脂肪、瘦体重和全身水分进行统计学比较（RSIGMA和SPSS）。
在三个月的治疗期间，患者的平均基础体重增加了3.54千克（p<0.001），这是以全身瘦体重增加2.24千克为代价的（p<0.01），而身体脂肪增加量（1.2千克）无统计学意义。全身水分增加了1.48升（p<0.001），体重指数增加了1.22千克/平方米（p<0.001）。
醋酸甲地孕酮治疗可使艾滋病相关恶病质患者的体重和体重指数持续且显著增加。体重的增加是以身体瘦体重为代价的。
