Zander R
Klin Wochenschr. 1978 Jun 1;56(11):567-73. doi: 10.1007/BF01477253.
To investigate the oxygen transport capacity of solutions for blood replacement the oxygen solubility coefficients (ml/ml atm) at 37 degrees C of 12 solutions for volume replacement were determined and compared with those of 12 solutions for parenteral nutrition, 4 electrolyte solutions and 5 solutions for osmotherapy. All solutions for volume replacement have lower values for oxygen solubility than human plasma which shows a very constant oxygen solubility value even under extreme conditions. For clinical use of volume replacement solutions it is recommended that the oxygen solubility of the substitute be considered when any of the following conditions presents: a) large amounts are infused (hemodilution), b) isobar of hyperbar oxygen therapy is employed (hyperoxia), c) the body temperature is lowered (hypothermia). This is valid especially in the case of any impairment of the microcirculation.
为研究用于血液替代的溶液的氧输送能力,测定了12种容量替代溶液在37℃时的氧溶解度系数(毫升/毫升·大气压),并与12种肠外营养溶液、4种电解质溶液和5种渗透疗法溶液的氧溶解度系数进行了比较。所有容量替代溶液的氧溶解度值均低于人血浆,即使在极端条件下人血浆的氧溶解度值也非常恒定。对于容量替代溶液的临床应用,建议在出现以下任何一种情况时考虑替代物的氧溶解度:a)大量输注(血液稀释),b)采用高压氧疗法的等压法(高氧),c)体温降低(低温)。这在微循环出现任何损害的情况下尤其适用。