Ikeda T, Kawakami K, Fujita J, Bandoh S, Yamadori I, Takahara J
First Department of Internal Medicine, Kagawa Medical University.
Intern Med. 1998 Apr;37(4):414-6. doi: 10.2169/internalmedicine.37.414.
A case of thymic squamous cell carcinoma producing interleukin-6 (IL-6) is reported. C-reactive protein (CRP), white blood cell (WBC) count, and serum IL-6 had been elevated, and normalized immediately after tumorectomy. IL-6 in the culture supernatant from the tumor was significantly elevated and the expression of IL-6 mRNA was demonstrated in the tumor by a reverse transcriptase polymerase chain reaction method. Immunohistochemical study demonstrated that tumor cells were stained positive with an anti-IL-6 antibody. IL-6 derived from the tumor cells reflected the increase CRP and WBC counts. This case suggested that asymptomatic elevation of acute-phase reactants might be clues for the diagnosis of an IL-6 producing tumor.
报告了1例产生白细胞介素-6（IL-6）的胸腺鳞状细胞癌病例。C反应蛋白（CRP）、白细胞（WBC）计数和血清IL-6曾升高，在肿瘤切除术后立即恢复正常。肿瘤培养上清液中的IL-6显著升高，通过逆转录聚合酶链反应法在肿瘤中证实了IL-6 mRNA的表达。免疫组织化学研究表明，肿瘤细胞用抗IL-6抗体染色呈阳性。肿瘤细胞产生的IL-6反映了CRP和WBC计数的增加。该病例提示，急性期反应物的无症状升高可能是诊断产生IL-6肿瘤的线索。
