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本文引用的文献

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Linear oligomeric potato spindle tuber viroid (PSTV) RNAs are accurately processed in vitro to the monomeric circular viroid proper when incubated with a nuclear extract from healthy potato cells.线性寡聚马铃薯纺锤块茎类病毒（PSTV）RNA 在与来自健康马铃薯细胞的核提取物孵育时，在体外被准确加工成单体环状类病毒。
EMBO J. 1987 Aug;6(8):2173-83. doi: 10.1002/j.1460-2075.1987.tb02488.x.
2
Chrysanthemum chlorotic mottle viroid: unusual structural properties of a subgroup of self-cleaving viroids with hammerhead ribozymes.菊花褪绿斑驳类病毒：具有锤头状核酶的自我切割类病毒亚组的异常结构特性
Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11262-7. doi: 10.1073/pnas.94.21.11262.
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Plant pathogenic RNAs and RNA catalysis.植物致病RNA与RNA催化作用。
Nucleic Acids Res. 1997 Jul 15;25(14):2683-9. doi: 10.1093/nar/25.14.2683.
4
A new sequence variant of Coleus blumei viroid 3 from the Coleus blumei cultivar 'Fairway Ruby'.来自彩叶草品种“Fairway Ruby”的彩叶草类病毒3的一个新序列变体。
Arch Virol. 1996;141(8):1377-86. doi: 10.1007/BF01718241.
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RNA secondary structure prediction using highly parallel computers.使用高度并行计算机进行RNA二级结构预测。
Comput Appl Biosci. 1995 Dec;11(6):685-92. doi: 10.1093/bioinformatics/11.6.685.
6
Mexican papita viroid: putative ancestor of crop viroids.墨西哥番木瓜类病毒：作物类病毒的假定祖先。
Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9397-401. doi: 10.1073/pnas.93.18.9397.
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Ribozymes: structure and mechanism in RNA catalysis.核酶：RNA催化的结构与机制
Trends Biochem Sci. 1996 Jun;21(6):220-4.
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A pseudoknot ribozyme structure is active in vivo and required for hepatitis delta virus RNA replication.假结核酶结构在体内具有活性，是丁型肝炎病毒RNA复制所必需的。
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Base and sugar requirements for RNA cleavage of essential nucleoside residues in internal loop B of the hairpin ribozyme: implications for secondary structure.发夹状核酶内环B中必需核苷酸碱基和糖基对RNA切割的要求：对二级结构的影响
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10
A photo-cross-linkable tertiary structure motif found in functionally distinct RNA molecules is essential for catalytic function of the hairpin ribozyme.在功能不同的RNA分子中发现的一种可光交联三级结构基序对于发夹状核酶的催化功能至关重要。
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椰子死亡类病毒中的特异性RNA自我切割：在滚环复制中发挥作用的潜力

Specific RNA self-cleavage in coconut cadang cadang viroid: potential for a role in rolling circle replication.

作者信息

Liu Y H, Symons R H

机构信息

Department of Plant Science, University of Adelaide, Waite Campus, SA, Australia.

出版信息

RNA. 1998 Apr;4(4):418-29.

PMID:9630248
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1369628/
Abstract

The rolling circle replication of the small, single-stranded viroid RNAs requires a specific processing reaction to produce monomeric RNAs that are ligated into the final circular form. For avocado sunblotch viroid, peach latent mosaic viroid, and chrysanthemum chlorotic mottle viroid, the hammerhead self-cleavage reaction is considered to provide this processing reaction. We have searched for a similar type of reaction in the 246-nt coconut cadang cadang viroid, the smallest viroid of the 24-member potato spindle tuber viroid (PSTV) group. RNA transcripts prepared from the cloned central or C domain of this viroid self-cleaved specifically after denaturation with methylmercuric hydroxide followed by incubation in the presence of spermidine but in the absence of added magnesium ions. The unique cleavage site was located in the bottom strand of the C domain within a potential hairpin structure that is conserved within members of all three subgroups of the PSTV group of viroids.

摘要

小型单链类病毒RNA的滚环复制需要特定的加工反应来产生连接成最终环状形式的单体RNA。对于鳄梨日斑类病毒、桃潜隐花叶类病毒和菊花褪绿斑驳类病毒，锤头状自我切割反应被认为可提供这种加工反应。我们在246个核苷酸的椰子死亡类病毒中寻找类似的反应类型，该病毒是24个成员的马铃薯纺锤块茎类病毒（PSTV）组中最小的类病毒。从该类病毒克隆的中央或C结构域制备的RNA转录本，在用氢氧化甲基汞变性后，在亚精胺存在但无添加镁离子的情况下孵育，会特异性地自我切割。独特的切割位点位于C结构域底部链内一个潜在的发夹结构中，该结构在PSTV类病毒所有三个亚组的成员中保守。