Guadaño A, González-Coloma A, de la Peña E
Centro de Ciencias Medioambientales, CSIC, c/Serrano 115 dpdo, 28006 Madrid, Spain.
Mutat Res. 1998 May 11;414(1-3):1-7. doi: 10.1016/s1383-5718(98)00032-1.
We have investigated the genotoxic activity of rotenone on three genetic endpoints, sister-chromatid exchanges (SCE), chromosome aberrations (CA) and micronuclei (MN) in human lymphocyte cultures in the presence and absence of a metabolic activation system (S9 mix). Our results indicate that rotenone increases the frequency of binucleated micronucleated (BNMN) cells and causes a delay in the cell cycle but does not increase the frequency of CA and SCE at the concentrations used. The presence of S9 mix reduces the genotoxic activity of rotenone.
我们研究了鱼藤酮在有和没有代谢活化系统（S9混合物）存在的情况下，对人淋巴细胞培养物中三个遗传终点的遗传毒性活性，即姐妹染色单体交换（SCE）、染色体畸变（CA）和微核（MN）。我们的结果表明，鱼藤酮增加了双核微核（BNMN）细胞的频率，并导致细胞周期延迟，但在所使用的浓度下，并未增加CA和SCE的频率。S9混合物的存在降低了鱼藤酮的遗传毒性活性。
