White R J
Mayo Clin Proc. 1978 Jul;53(7):450-8.
Through the application of low-temperature technology, the critical limits of circulatory arrest to the mammalian brain--the most complex of all body organ systems--can be significantly extended. This presentation reviews three recently developed methods of cooling the brain. The first demonstrates the unique preservation of cerebral tissue as an isolated organ near 0 degrees C with donor perfusion reanimation. The second emphasizes the ability of the intact animal to literally cool its own brain when a simple extracorporeal shunt is utilized. The third outlines a technique of direct hypothermic infusion of the ventricular pathways to achieve deep temperature reductions in brain tissue. Their clinical applications and implications are discussed.
通过应用低温技术，循环停止对哺乳动物大脑（身体所有器官系统中最复杂的）的临界极限可以显著延长。本报告回顾了三种最近开发的脑部降温方法。第一种方法展示了在接近0摄氏度时，作为一个孤立器官的脑组织在供体灌注复苏下的独特保存。第二种方法强调了当使用简单的体外分流时，完整动物能够自行冷却其大脑的能力。第三种方法概述了一种直接向脑室途径进行低温灌注以实现脑组织深度降温的技术。并讨论了它们的临床应用及意义。
