抗有丝分裂环肽乌斯他毒素F的分离与结构：与同源肽乌斯他毒素B的化学相关性
Isolation and structure of an antimitotic cyclic peptide, ustiloxin F: chemical interrelation with a homologous peptide, ustiloxin B.
作者信息
Koiso Y, Morisaki N, Yamashita Y, Mitsui Y, Shirai R, Hashimoto Y, Iwasaki S
机构信息
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1998 Apr;51(4):418-22. doi: 10.7164/antibiotics.51.418.
PMID:9630863
Abstract
Ustiloxin F, a microtubule inhibitor, was isolated as a minor metabolite of Ustilaginoidea virens. The structure was determined from the spectral data and by chemical interrelation to ustiloxin B through reductive removal of the sulfoxide-containing side chain of ustiloxin B to give ustiloxin F. Ustiloxin F inhibited microtubule assembly with an IC50 value of 10.3 microM.
摘要
稻曲毒素F是一种微管抑制剂，作为稻绿核菌的一种次要代谢产物被分离出来。其结构通过光谱数据以及通过对稻曲毒素B含亚砜侧链进行还原去除以得到稻曲毒素F，从而与稻曲毒素B建立化学关联来确定。稻曲毒素F抑制微管组装，IC50值为10.3微摩尔。
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