拉瑞菌素是红球菌属K01 - B0171产生的抗分枝杆菌肽，具有套索结构。
Lariatins, antimycobacterial peptides produced by Rhodococcus sp. K01-B0171, have a lasso structure.
作者信息
Iwatsuki Masato, Tomoda Hiroshi, Uchida Ryuji, Gouda Hiroaki, Hirono Shuichi, Omura Satoshi
机构信息
Kitasato Institute, Kitasato University, Minato-ku, Tokyo 108, Japan.
出版信息
J Am Chem Soc. 2006 Jun 14;128(23):7486-91. doi: 10.1021/ja056780z.
Two antimycobacterial agents, lariatins A and B, were isolated from the culture broth of Rhodococcus sp. K01-B0171. Their structures were elucidated by spectral analysis and advanced protein chemical methods to be unique cyclic peptides, which consist of 18 and 20 L-amino acid residues with an internal linkage between the gamma-carboxyl group of Glu8 and the alpha-amino group of Gly1. The three-dimensional structure of lariatin A deduced from NMR data by dynamical simulated annealing method indicates that the tail segment (Trp9-Pro18) passes through the ring segment (Gly1-Glu8) to form a 'lasso' structure.
从红球菌属菌株K01-B0171的培养液中分离出两种抗分枝杆菌剂，即套索菌素A和B。通过光谱分析和先进的蛋白质化学方法阐明了它们的结构，发现它们是独特的环肽，由18个和20个L-氨基酸残基组成，在Glu8的γ-羧基和Gly1的α-氨基之间存在内部连接。通过动态模拟退火方法从核磁共振数据推导出的套索菌素A的三维结构表明，尾部片段（Trp9-Pro18）穿过环部片段（Gly1-Glu8）形成“套索”结构。
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