Coger R W, Dymond A M, Serafetinides E A, Lowenstam I, Pearson D
Biol Psychiatry. 1976 Aug;11(4):435-43.
Alcohol withdrawal has been characterized in terms of some EEG changes but seldom in terms of the averaged evoked response. Characteristics of the AER, such as amplitude, latency, and the least-squares slope of the AER amplitude as a function of stimulus intensity, have been found to change as a function of arousal and to separate some psychiatric groups. Seventeen alcoholics in withdrawal, 27 stabilized alcoholics, and 30 control volunteer subjects participated in an experiment to determine the changes in AER characteristics in withdrawal. Four stimulus intensities were presented to the subjects from a Grass PS 22 photostimulator with the flash sources 102 cm from the nasion. AER amplitude, the slope of the amplitude as a function of stimulus intensity, and bilateral symmetry scores were calculated for group comparison. Withdrawal and stabilized alcoholics were found to have significantly greater AER amplitudes at all intensity levels. Greater A-I slope from the right hemisphere and higher symmetry were found for withdrawal alcoholics than the other two groups.
酒精戒断已根据一些脑电图变化进行了特征描述，但很少根据平均诱发电位来描述。已发现平均诱发电位的特征，如振幅、潜伏期以及平均诱发电位振幅作为刺激强度函数的最小二乘斜率，会随着觉醒状态而变化，并能区分一些精神疾病组。17名处于戒断期的酗酒者、27名病情稳定的酗酒者和30名对照志愿者参与了一项实验，以确定戒断期平均诱发电位特征的变化。使用Grass PS 22光刺激器向受试者呈现四种刺激强度，闪光光源距离鼻根102厘米。计算平均诱发电位振幅、振幅作为刺激强度函数的斜率以及双侧对称分数，用于组间比较。发现处于戒断期的酗酒者和病情稳定的酗酒者在所有强度水平下的平均诱发电位振幅都显著更大。与其他两组相比，处于戒断期的酗酒者右半球的A-I斜率更大，对称性更高。
