Rho B, Glick S D
Department of Pharmacology and Neuroscience (A-136), Albany Medical College, NY 12208, USA.
Neuroreport. 1998 May 11;9(7):1283-5. doi: 10.1097/00001756-199805110-00004.
Ibogaine, an alkaloid found in the root bark of the African shrub Tabernanthe iboga, has been claimed to interrupt opioid dependence in humans; in animals, it has been shown to inhibit morphine self-administration and to attenuate signs of morphine withdrawal. However, ibogaine has some neurotoxicity, and because of this, efficacious and safer congeners of ibogaine have been sought, 18-Methoxycoronaridine (18-MC), a novel iboga alkaloid congener, has been shown, in animals, to mimic the effects of ibogaine on morphine self-administration without producing any ibogaine-like neurotoxiticity. In the present study, 18-MC was shown to attenuate five of seven signs of morphine withdrawal in rats. The data suggest that 18-MC will ameliorate symptoms of opioid dependence in humans.
伊波加因是一种存在于非洲灌木伊博格（Tabernanthe iboga）根皮中的生物碱，据称它能中断人类对阿片类药物的依赖；在动物实验中，它已被证明能抑制吗啡的自我给药，并减轻吗啡戒断症状。然而，伊波加因具有一定的神经毒性，因此，人们一直在寻找伊波加因更有效、更安全的类似物。18-甲氧基冠狗牙花定碱（18-MC）是一种新型的伊波加生物碱类似物，在动物实验中，它已被证明能模拟伊波加因对吗啡自我给药的作用，且不会产生任何类似伊波加因的神经毒性。在本研究中，18-MC被证明能减轻大鼠吗啡戒断七个症状中的五个。数据表明，18-MC将改善人类阿片类药物依赖的症状。
