Gerozissis K, de Saint-Hilaire Z, Python A, Rouch C, Orosco M, Nicolaidis S
Neurobiologie des Régulations, CNRS UPR 9054, Collège de France, Paris, France.
Neuroreport. 1998 May 11;9(7):1327-30. doi: 10.1097/00001756-199805110-00014.
Prostaglandin (PG) E2 production was assessed in freely moving rats using the technique of microdialysis in the prefrontal cortex associated with parallel cortical EEG recordings. PGE2 concentrations were 40% higher during wakefulness than during slow wave sleep. PGE2 values varied during wakefulness with a maximal increase in the middle of the stage and a drop towards lower values before the occurrence of slow wave sleep. These variations were similar to those observed previously in the rostromedial hypothalamus, where PGE2 concentration was 2.6 times lower than that in the cortex. These data document a positive correlation between cortical EEG activation and PGE2 levels. Taken together with pharmacological data on the awakening effect of centrally administered PGE2, these observations are in favor of an involvement of PGE2 in the generation of wakefulness.
使用微透析技术并结合平行的皮层脑电图记录，在自由活动的大鼠前额叶皮层中评估前列腺素（PG）E2的产生。清醒期间的PGE2浓度比慢波睡眠期间高40%。PGE2值在清醒期间有所变化，在阶段中期最大程度增加，在慢波睡眠出现前降至较低值。这些变化与之前在下丘脑嘴内侧观察到的相似，那里的PGE2浓度比皮层中的低2.6倍。这些数据证明皮层脑电图激活与PGE2水平之间存在正相关。结合关于中枢给予PGE2的觉醒作用的药理学数据，这些观察结果支持PGE2参与觉醒的产生。
