2-肼基喹啉的糖腙及其抗菌活性。
Sugarhydrazones of 2-hydrazinoquinolines and their antimicrobial activity.
作者信息
Khodair A I, Ibrahim E S, Diab A M, Abd-el Aziz M M, Omar B M, el Ashry E S
机构信息
Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.
出版信息
Pharmazie. 1998 May;53(5):294-300.
PMID:9631498
Abstract
Sugar hydrazones from 2-hydrazinoquinoline, 2-hydrazino-6-methyllepidine, 6-chloro-2-hydrazino lepidine, 7-chloro-2-hydrazinolepidine, and 7-chloro-2-hydrazino-3-nitroquinoline were prepared. Their acetylation, benzoylation, periodate oxidation, oxidation with lead tetraacetate and bromination have been investigated. The antimicrobial activities of the hydrazones were evaluated. Some compounds showed moderate activity.
摘要
制备了来自2-肼基喹啉、2-肼基-6-甲基勒皮啶、6-氯-2-肼基勒皮啶、7-氯-2-肼基勒皮啶和7-氯-2-肼基-3-硝基喹啉的糖腙。研究了它们的乙酰化、苯甲酰化、高碘酸盐氧化、四乙酸铅氧化和溴化反应。评估了这些腙的抗菌活性。一些化合物表现出中等活性。
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