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具有潜在抗菌和抗寄生虫活性的喹啉腙类化合物

[Quinolylhydrazones with potential antimicrobial and antiparasitic activity].

作者信息

Pellerano C, Savini L, Brizzi V

出版信息

Farmaco Sci. 1985 Jul;40(7):486-92.

PMID:4043372
Abstract

Quinolinehydrazones prepared by condensation of hydrazinoquinolines with 1-phenyl-2,5-dimethyl-3-pyrrolcarboxaldehyde, 2-chloro-4-dimethylaminobenzaldehyde and 2,6-dichlorobenzaldehyde are described. All compounds were tested in vitro for antimicrobial activity, the results obtained are shown and discussed. The quinolinehydrazones of the 1-phenyl-2,5-dimethyl-3-pyrrolcarboxaldehyde were tested in vivo against Hymenolepis nana and Taenia taeniaeformis and proved inactive.

摘要

描述了通过肼基喹啉与1-苯基-2,5-二甲基-3-吡咯甲醛、2-氯-4-二甲基氨基苯甲醛和2,6-二氯苯甲醛缩合制备的喹啉腙。所有化合物均进行了体外抗菌活性测试,并展示和讨论了所得结果。1-苯基-2,5-二甲基-3-吡咯甲醛的喹啉腙在体内针对微小膜壳绦虫和豆状带绦虫进行了测试,结果证明无活性。

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