某些O-(5-芳基-1,2,4-三唑-3-基-乙基)苯甲醛肟和O-(5-芳基-1,3,4-恶二唑-2-基-乙基)苯甲醛肟的合成、亲脂性及抗菌性能
Synthesis, lipophilicity and antimicrobial properties of some O-(5-aryl-1,2,4-triazol-3-yl-ethyl)benzaldoximes and O-(5-aryl-1,3,4-oxydiazol-2-yl-ethyl)benzaldoximes.
作者信息
Papakonstantinou-Garoufalias S, Marakos P, Tsantili-Kakoulidou A, Chytyroglou-Ladas A
机构信息
Department of Pharmacy, University of Athens, Greece.
出版信息
Pharmazie. 1998 May;53(5):300-2.
PMID:9631499
Abstract
The synthesis of benzaldehyde oximethers with suitably substituted 1,2,4-triazoles and 1,3,4-oxadiazoles from the corresponding benzaldoximes is described. The lipophilicity of the compounds was measured as well as their antimicrobial and antifungal activity in vitro. Certain compounds showed relatively significant activity against Bacillus subtilis.
摘要
描述了由相应的苯甲醛肟合成带有适当取代基的1,2,4-三唑和1,3,4-恶二唑的苯甲醛肟醚。测定了这些化合物的亲脂性以及它们的体外抗菌和抗真菌活性。某些化合物对枯草芽孢杆菌显示出相对显著的活性。
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