Vega Matuszcyk J, Larsson K, Eriksson E
Department of Psychology, University of Göteborg, Sweden.
Pharmacol Biochem Behav. 1998 Jun;60(2):527-32. doi: 10.1016/s0091-3057(98)00010-0.
A male rat put in an open-field arena in which it is free to spend time in the vicinity of--but not in contact with--an estrous female, or in the vicinity of a male, usually spends more time with the female than with the male or elsewhere. Tentatively, the percentage of time spent in the vicinity of the female in this paradigm may be regarded as a measure of sexual motivation. In humans, treatment with selective serotonin reuptake inhibitors (SSRIs) may cause reduced libido. To investigate to what extent serotonin reuptake inhibition influences sexual motivation also in rats, we have tested the effect of subchronic treatment with fluoxetine on the behavior in the sexual motivation test described above; in addition, the effect of fluoxetine on male copulatory behavior was studied. Fluoxetine significantly reduced sexual motivation at subchronic but not at acute administration; moreover, fluoxetine-treated rats displayed an increased ejaculation latency. It is concluded that humans and rats respond similarly to the SSRI fluoxetine with respect to various aspects of sexual behavior.
将一只雄性大鼠放入一个旷场实验区域，在该区域中它可以自由地在处于发情期的雌性大鼠附近停留——但不与之接触——或者在雄性大鼠附近停留，通常情况下，它与雌性大鼠待在一起的时间要比与雄性大鼠或在其他地方待的时间长。在此实验范式中，暂定在雌性大鼠附近停留的时间百分比可被视为性动机的一种衡量指标。在人类中，使用选择性5-羟色胺再摄取抑制剂（SSRI）进行治疗可能会导致性欲降低。为了研究5-羟色胺再摄取抑制在大鼠中对性动机的影响程度，我们测试了亚慢性给予氟西汀对上述性动机测试中行为的影响；此外还研究了氟西汀对雄性交配行为的影响。氟西汀在亚慢性给药时显著降低了性动机，但急性给药时未出现此现象；而且，经氟西汀治疗的大鼠射精潜伏期延长。研究得出结论，在性行为的各个方面，人类和大鼠对SSRI氟西汀的反应相似。
