Franchini M, de Gironcoli M, Gandini G, Vassanelli A, Rocca P, Benedetti F, Aprili G
Servizio di Immunoematologia e Trasfusione, Ospedale Policlinico, Verona, Italy.
Bone Marrow Transplant. 1998 May;21(10):1071-3. doi: 10.1038/sj.bmt.1701226.
We report a bone marrow transplant which was HLA matched, with major and minor ABO and minor RhD incompatibility (anti-RhD antibody) between the donor and recipient. When engraftment occurred, the recipient developed an anti-RhD antibody of donor origin detected by direct and indirect antiglobulin tests (DAT, IAT) and showed signs of mild hemolytic anemia. With the disappearance of the recipient RBCs, the DAT became negative and the hemolysis disappeared, while the anti-RhD alloantibody persisted in the patient's serum. This case emphasizes the importance of close immuno-hematological monitoring in patients undergoing allogeneic BMT with ABO-RhD incompatibility between recipient and donor.
我们报告了一例骨髓移植病例，供体与受体之间HLA匹配，但存在主要和次要ABO血型以及次要RhD血型不合（抗RhD抗体）。移植成功后，受体通过直接和间接抗球蛋白试验（DAT、IAT）检测出供体来源的抗RhD抗体，并出现轻度溶血性贫血迹象。随着受体红细胞消失，DAT转为阴性，溶血现象消失，而抗RhD同种抗体仍存在于患者血清中。该病例强调了在供体与受体存在ABO-RhD血型不合的异基因骨髓移植患者中进行密切免疫血液学监测的重要性。
