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Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects.

作者信息

Ennis M D, Ghazal N B, Hoffman R L, Smith M W, Schlachter S K, Lawson C F, Im W B, Pregenzer J F, Svensson K A, Lewis R A, Hall E D, Sutter D M, Harris L T, McCall R B

机构信息

Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 49001, USA.

出版信息

J Med Chem. 1998 Jun 18;41(13):2180-3. doi: 10.1021/jm980137o.

DOI:10.1021/jm980137o
PMID:9632349
Abstract
摘要

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Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents.选择性口服活性5-羟色胺1D受体激动剂作为潜在的抗偏头痛药物。
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