用约氏疟原虫裂殖子表面蛋白1 DNA疫苗保护小鼠免受约氏疟原虫子孢子攻击。
Protection of mice against Plasmodium yoelii sporozoite challenge with P. yoelii merozoite surface protein 1 DNA vaccines.
作者信息
Becker S I, Wang R, Hedstrom R C, Aguiar J C, Jones T R, Hoffman S L, Gardner M J
机构信息
Malaria Program, Naval Medical Research Institute, Bethesda, Maryland 20889-5607, USA.
出版信息
Infect Immun. 1998 Jul;66(7):3457-61. doi: 10.1128/IAI.66.7.3457-3461.1998.
Abstract
Immunization of mice with DNA vaccines encoding the full-length form and C and N termini of Plasmodium yoelii merozoite surface protein 1 provided partial protection against sporozoite challenge and resulted in boosting of antibody titers after challenge. In C57BL/6 mice, two DNA vaccines provided protection comparable to that of recombinant protein consisting of the C terminus in Freund's adjuvant.
摘要
用编码约氏疟原虫裂殖子表面蛋白1全长形式及其C端和N端的DNA疫苗免疫小鼠，可提供部分抗子孢子攻击的保护作用，并在攻击后导致抗体滴度升高。在C57BL/6小鼠中，两种DNA疫苗提供的保护作用与弗氏佐剂中含C端的重组蛋白相当。
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Protection of mice against Plasmodium yoelii sporozoite challenge with P. yoelii merozoite surface protein 1 DNA vaccines.用约氏疟原虫裂殖子表面蛋白1 DNA疫苗保护小鼠免受约氏疟原虫子孢子攻击。
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