弗朗西斯菌和李斯特菌感染中的非特异性早期保护性免疫可能依赖于淋巴细胞。
Nonspecific early protective immunity in Francisella and Listeria infections can be dependent on lymphocytes.
作者信息
Elkins K L, MacIntyre A T, Rhinehart-Jones T R
机构信息
Laboratory of Mycobacteria, Division of Bacterial Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852, USA.
出版信息
Infect Immun. 1998 Jul;66(7):3467-9. doi: 10.1128/IAI.66.7.3467-3469.1998.
Abstract
Normal mice, but not lymphocyte-deficient or B-cell-deficient mice, given a sublethal infection of Francisella tularensis LVS survive a secondary lethal challenge of more than 10,000 50% lethal doses given 3 days later. In this work, we show that similar early protection that is also strongly lymphocyte dependent operates in Listeria monocytogenes infection. Since sublethal infection with either LVS or L. monocytogenes protects against heterologous lethal challenge, this early protection is nonspecific.
摘要
正常小鼠而非淋巴细胞缺陷或B细胞缺陷小鼠，在接受土拉弗朗西斯菌LVS亚致死感染后，能在3天后接受超过10,000个50%致死剂量的二次致死性攻击中存活下来。在这项研究中，我们表明，在单核细胞增生李斯特菌感染中也存在类似的早期保护作用，且这种保护作用也强烈依赖淋巴细胞。由于用LVS或单核细胞增生李斯特菌进行亚致死感染均可抵御异源致死性攻击，因此这种早期保护是非特异性的。
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