Callagari G, D'Armini A M, Vigano M, Volpato G, Arbustini E, Morbini P, Fracchia C
Salvatore Maugeri Foundation IRCCS, Pulmonary Division, Medical Center of Montescano, Pavia, Italy.
Monaldi Arch Chest Dis. 1998 Feb;53(1):30-3.
The main long-term complication after lung transplantation is chronic rejection in terms of obliterative bronchiolitis; when therapy does not arrest the progression of the airflow obstruction, lung retransplantation seems to be. at present, the only strategy in the management of chronic rejection. We report the 12 month follow-up of a single lung retransplantation in a 21 yr old female who had received a heart-lung transplantation 35 months previously for Eisenmenger syndrome. The patient had excellent first allograft function and quality of life for 26 months, then progressively deteriorated due to the occurrence of obliterative bronchiolitis, and further worsened in the following 9 months. At that time, she underwent left lung retransplantation, based on her negative history of infection, low rate of acute rejection, ambulatory status, and young age. She is now doing well at 12 months after retransplantation and her forced expiratory volume in one second is still improving, p thus justifying both retransplantation and hopeful expectation.
肺移植术后主要的长期并发症是闭塞性细支气管炎所致的慢性排斥反应；当治疗无法阻止气流阻塞的进展时，肺再次移植似乎是目前治疗慢性排斥反应的唯一策略。我们报告了一名21岁女性单肺再次移植的12个月随访情况，该女性在35个月前因艾森曼格综合征接受了心肺移植。患者首次移植的移植物功能良好，生活质量优良达26个月，随后因闭塞性细支气管炎的发生而逐渐恶化，并在接下来的9个月中进一步加重。当时，鉴于其无感染史、急性排斥反应发生率低、可走动状态以及年轻等因素，她接受了左肺再次移植。再次移植后12个月时她目前情况良好，其一秒用力呼气量仍在改善，因此再次移植是合理的，前景也充满希望。
