Spriggs A I, Holt J M, Bedford J
Blood. 1976 Oct;48(4):595-9.
In a case of classical myelomatosis treated with melphalan, a clone of cells with a chromosomal abnormality was found in the bone marrow during remission. There was good reason to think that the hemopoietic cells, rather than plasmacytoma cells, were implicated. Although the clone persisted, no evidence of leukemia developed over a period of observation of 2 yr. The anomaly was interpreted as a duplication of part of the long arm of chromosome 1, which appeared to involve the segment q21 to q31.
在一例用美法仑治疗的经典型骨髓瘤病例中，缓解期骨髓中发现了一个具有染色体异常的细胞克隆。有充分理由认为涉及的是造血细胞而非浆细胞瘤细胞。尽管该克隆持续存在，但在2年的观察期内未出现白血病证据。这种异常被解释为1号染色体长臂部分的重复，似乎涉及q21至q31节段。
