Dahlke M B, Nowell P C
Br J Haematol. 1975 Sep;31(1):111-6. doi: 10.1111/j.1365-2141.1975.tb00838.x.
Two patients with multiple myeloma and one patient with a plasma-cytoma are reported in whom acute leukaemia developed following long-term treatment with melphalan. Each patient had a complete remission of the plasma cell disorder during which time the bone marrow was moderately to severely hypoplastic. The end of the clinical remission was heralded by a dyserythropoietic anaemia which persisted several months before the emergence of the terminal acute leukaemia. Marked chromosomal abnormalities were observed in marrow cells during the dyserythropoietic phase.
报告了两名多发性骨髓瘤患者和一名浆细胞瘤患者，他们在接受美法仑长期治疗后发生了急性白血病。每名患者的浆细胞疾病均完全缓解，在此期间骨髓呈中度至重度发育不全。临床缓解结束时出现了红细胞生成异常性贫血，这种贫血持续了数月后才出现终末期急性白血病。在红细胞生成异常阶段，骨髓细胞中观察到明显的染色体异常。
