阿司匹林对豚鼠肺脏的双重作用。
Dual effects of aspirin in guinea-pig lungs.
作者信息
Mielens E, Rosenberg F J
出版信息
Br J Pharmacol. 1976 Aug;57(4):495-500. doi: 10.1111/j.1476-5381.1976.tb10376.x.
Dual effects of aspirin were demonstrated in guinea-pig lungs: (a) aspirin (3.3 mg/kg i.v.) antagonized bronchoconstriction induced by slow reacting substance of anaphylaxis (SRS-A); (b) aspirin produced bronchoconstriction when injected in the presence of propranolol into guinea-pigs in vivo at 330 mg/kg, or into guinea-pig isolated lungs in vitro as a 4% solution (40 mg/ml). 2 The severity of bronchoconstriction following administration of aspirin was directly related to the degree of beta-adrenoceptor blockade and to the age of the guinea-pigs. Aspirin-induced bronchoconstriction was prevented in vivo and in vitro by atropine and it could be reversed in vivo by atropine. Aspirin-induced bronchoconstriction was not inhibited by vagotomy or phenoxybenzamine. 3 These data suggest that the mechanism involved in aspirin-induced bronchoconstriction may be local cholinergic stimulation and that reduced beta-adrenergic drive may be a predisposing factor.
阿司匹林在豚鼠肺中表现出双重作用
(a) 阿司匹林（静脉注射3.3毫克/千克）可拮抗过敏反应慢反应物质（SRS-A）诱导的支气管收缩；(b) 当在普萘洛尔存在的情况下，以330毫克/千克的剂量给豚鼠体内注射阿司匹林，或以4%的溶液（40毫克/毫升）给豚鼠离体肺注射时，阿司匹林会引起支气管收缩。2 服用阿司匹林后支气管收缩的严重程度与β-肾上腺素能受体阻滞程度和豚鼠年龄直接相关。阿司匹林诱导的支气管收缩在体内和体外均可被阿托品预防，且在体内可被阿托品逆转。阿司匹林诱导的支气管收缩不受迷走神经切断术或酚苄明的抑制。3 这些数据表明，阿司匹林诱导支气管收缩的机制可能是局部胆碱能刺激，而β-肾上腺素能驱动力降低可能是一个诱发因素。
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