吗啡处理后突触体的钙耗竭。
Calcium depletion of synaptosomes after morphine treatment.
作者信息
Cardenas H L, Ross D H
出版信息
Br J Pharmacol. 1976 Aug;57(4):521-6. doi: 10.1111/j.1476-5381.1976.tb10379.x.
Abstract
It was confirmed that morphine administration in vivo produced a selective decrease in the calcium content of synaptosomal fractions prepared from rat cerebral cortices. This effect was prevented by naloxone. 2 After morphine or naloxone, there were no changes in the sodium, potassium and magnesium contents of any of the seven subcellular fractions tested. 3 Since the selective calcium loss was found to occur from fractions similar to those reported to exhibit opiate receptor binding, it is concluded that calcium may play a role in the action of narcotic agonist drugs.
摘要
已证实，体内给予吗啡会使从大鼠大脑皮层制备的突触体组分中的钙含量选择性降低。纳洛酮可阻止这种作用。2给予吗啡或纳洛酮后，所测试的七个亚细胞组分中的钠、钾和镁含量均无变化。3由于发现选择性钙流失发生在与据报道显示阿片受体结合的组分相似的组分中，因此得出结论，钙可能在麻醉激动剂药物的作用中起作用。
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