Stohlawetz P, Stiegler G, Jilma B, Dettke M, Höcker P, Panzer S
Clinic for Blood Group Serology and Transfusion Medicine, University of Vienna, Austria.
Transfusion. 1998 May;38(5):454-8. doi: 10.1046/j.1537-2995.1998.38598297214.x.
Little is known about the effects of long-term plateletpheresis on the donors' health. The aim of this study was to examine the effect of plateletpheresis on the time course of reticulated platelet counts as an estimate for thrombopoiesis.
The effect of moderate platelet depletion on the thrombopoietic capacity was evaluated prospectively by the measurement of reticulated platelets before and after plateletpheresis and on the following 4 days. Donors undergoing plateletpheresis for the first time were compared to those donating platelets every other week for more than 18 months.
The median levels of reticulated platelets were significantly lower in frequent donors than in new donors. In new donors, there was a transient increase in the median levels of reticulated platelets on Day 3 after apheresis, and baseline values were reached again on Day 4. On the contrary, in repeat donors, there was a sustained rise in the percentage of reticulated platelets from Days 1 through 4. However, this increase in reticulated platelet counts was still less than that seen in new donors. There was no difference in the peripheral blood platelet counts in the two groups at any time point.
These findings suggest that repeat platelet donation might lead to a relative exhaustion of thrombopoiesis, as evidenced by the low levels of reticulated platelets exhibited by repeat donors. The reticulated platelet count can be used to monitor the thrombopoietic capacity of long-term platelet donors.
关于长期血小板单采对献血者健康的影响，人们了解甚少。本研究的目的是检测血小板单采对网织血小板计数时间进程的影响，以此作为血小板生成的一项评估指标。
通过在血小板单采前、后及随后4天测量网织血小板，前瞻性评估适度血小板减少对血小板生成能力的影响。将首次进行血小板单采的献血者与每隔一周献血超过18个月的献血者进行比较。
频繁献血者中网织血小板的中位数水平显著低于初次献血者。在初次献血者中，单采后第3天网织血小板的中位数水平出现短暂升高，并在第4天再次达到基线值。相反，在重复献血者中，从第1天到第4天，网织血小板的百分比持续上升。然而，这种网织血小板计数的增加仍低于初次献血者。两组在任何时间点的外周血血小板计数均无差异。
这些发现表明，重复献血可能导致血小板生成相对耗竭，重复献血者中网织血小板水平较低即证明了这一点。网织血小板计数可用于监测长期血小板献血者的血小板生成能力。
