Quantitative trait loci on chromosomes 1 and 4 affect lipid phenotypes in the rat.

The spontaneously hypertensive rat (SHR/Mol) and the spontaneously diabetic BB/OK rat were crossed, and the F1 hybrids were backcrossed onto the BB/OK rat in order to search for quantitative trait loci (QTL) affecting serum total cholesterol and triglycerides on chromosomes 1, 3, 4, 10, 13, 18, and X. On chromosome 4 a QTL for triglyceride levels (lod score 3.3) was found within the region flanked by the D4Mit9 and Il-6 markers. Suggestive linkage (lod score 1.9) was found for total cholesterol on chromosome 4 at the Spr locus. Also, on chromosome 1 suggestive linkage for both investigated traits was found at marker D1Mit14 (lod score 1.9 for triglycerides, 2.1 for total cholesterol). The results of the study could contribute to the explanation of the genetic basis of lipid abnormalities, which are a common feature of pathological disorders such as coronary heart disease, hypertension, or non-insulin-dependent diabetes.