Kuzurman P A, Sharpatyĭ V A
N.M. Emanuel Institute of Biochemical Physics Russian Academy of Sciences, Moscow.
Radiats Biol Radioecol. 1998 Mar-Apr;38(2):147-55.
By steric computer modelling of five types of 2-deoxyribosyl radicals and their molecular products generated in DNA by radiation as a result of R + InH = RH + In reaction the displacement of DNA bases (maximum--for C'1 atoms and minimum for C'3 ones) has been determined. Literature data on the DNA decay in the irradiated cells, and in DNA frozen solutions as well as the data on radiolysis of compounds modelling separate DNA fragments allowed to offer a general scheme of the every 2-deoxyribosyl radical transformation and to calculate a balance between the intermediate and final molecular products (processes) of the 2-deoxyribosyl radiolysis. The DNA conformation change due to the 2-deoxyribosyl stereoisomers formation at C'3 and C'4 atoms is discussed as one of the suggested reasons for genetic radiation mutation.
通过对五种类型的2-脱氧核糖基自由基及其在DNA中由辐射通过R + InH = RH + In反应产生的分子产物进行空间计算机建模，已确定了DNA碱基的位移（C'1原子处最大，C'3原子处最小）。关于辐照细胞中DNA衰变、DNA冷冻溶液中的数据以及模拟单独DNA片段的化合物的辐射分解数据，使得能够提供每个2-脱氧核糖基自由基转化的一般方案，并计算2-脱氧核糖基辐射分解的中间和最终分子产物（过程）之间的平衡。讨论了由于在C'3和C'4原子处形成2-脱氧核糖基立体异构体而导致的DNA构象变化，这是遗传辐射突变的一个可能原因。
