Sharpatyĭ V A
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow.
Radiats Biol Radioecol. 1997 Jul-Aug;37(4):508-11.
Analysis of the DNA and modeling its certain fragments substances radiolysis data allows to attribute the cardinal role to the primary 2-deoxyribosyl radicals in the processes of the breaks (C'3, C'5) and alkali-labile sites (C'1, C'2, C'4) in DNA strands, of the free bases appearance (C'3, C'5). The higher yield of bases destruction in DNA is explained by the transferring of a damage (unpaired electron) from 2-deoxyribosyl to a base within one nucleotide.
对DNA进行分析并对其特定片段的物质辐射分解数据进行建模，有助于确定初级2-脱氧核糖基自由基在DNA链断裂（C'3、C'5）和碱不稳定位点（C'1、C'2、C'4）形成过程以及游离碱基出现（C'3、C'5）过程中的关键作用。DNA中碱基破坏产率较高的原因是损伤（未配对电子）在一个核苷酸内从2-脱氧核糖基转移到了碱基上。
