Griver J, Perry B J, Uttley D
Br J Radiol. 1976 Sep;49(585):788-93. doi: 10.1259/0007-1285-49-585-788.
A previously described method for the computer analysis of radioisotope brain scans has been further developed. A patient scan is matched with a series of "normal" scans to find the closest fit and the "normal" scan is then subtracted from the patient scan. The results are displayed in terms of the standard deviation from the normal. In a clinical trial the computer assessments were found to be less accurate than those of two groups of observers. One reason for these disappointing results is related to the simple criteria used to choose and fit the best "normal" to a particular patient scan. A second reason is the optimization of the scanner/photoscan combination to 99Tcm pertechnetate as a brain scanning agent which results in patient-to-patient variation becoming more important. This reduces the potential of a simple numerical analysis to improve results.
一种先前描述的用于放射性同位素脑扫描计算机分析的方法得到了进一步发展。将患者扫描图像与一系列“正常”扫描图像进行匹配，以找到最匹配的图像，然后从患者扫描图像中减去“正常”扫描图像。结果以相对于正常情况的标准差来显示。在一项临床试验中，发现计算机评估不如两组观察者的评估准确。这些令人失望的结果的一个原因与用于为特定患者扫描选择和拟合最佳“正常”图像的简单标准有关。第二个原因是将扫描仪/光扫描组合优化用于高锝[99mTc]酸盐作为脑扫描剂，这使得患者之间的差异变得更加重要。这降低了简单数值分析改善结果的潜力。
