Mosolov S N
Zh Nevrol Psikhiatr Im S S Korsakova. 1998;98(5):12-9.
Modern period of psychopharmacology development is characterized by seven main features: changes in both clinical picture and course of psychic diseases; the use of psychotropic drug in general medicine; some new nosologic entities in ICD-10 which require of more accurate definition of the methods of therapy; progress in the study of biologic mechanisms of psychotropic drugs' action; appearance of numerous little-known preparations; discovery of some new aspects in action of well-known drugs; increase of the number of patients resistent to psychopharmacotherapy. Traditional and original classifications of psychotropic drugs are presented. Clinical analysis revealed that clear limits between separate groups of drugs are relative. Between the separate classes "transitional" drugs exist with distinct properties of both groups. Such drugs are thymoneuroleptics, thymotranquilizers, antidepressants with nootropic and neuroleptic properties, tranquilonootrops, etc. In accordance with the conception of "ideal" drug each class of psychotropic drugs was analyzed in terms of main advantages and defects. The advantages of some new drugs are considered.
精神疾病的临床表现和病程发生变化；精神药物在普通医学中的应用；《国际疾病分类第10版》中一些新的疾病实体，需要更准确地定义治疗方法；精神药物作用的生物学机制研究取得进展；出现了许多鲜为人知的制剂；发现了一些知名药物作用的新方面；对精神药物治疗产生耐药性的患者数量增加。介绍了精神药物的传统分类和原创分类。临床分析表明，不同药物组之间的明确界限是相对的。在不同类别之间存在具有两组明显特性的“过渡性”药物。这类药物有胸腺神经阻滞剂、胸腺镇静剂、具有益智和抗精神病特性的抗抑郁药、镇静益智药等。根据“理想”药物的概念，从主要优点和缺陷方面对每一类精神药物进行了分析。考虑了一些新药的优点。
