核质运输：驱动和引导运输

Nucleocytoplasmic transport: driving and directing transport.

作者信息

Cole C N, Hammell C M

机构信息

Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.

出版信息

Curr Biol. 1998 May 21;8(11):R368-72. doi: 10.1016/s0960-9822(98)70239-8.

DOI:10.1016/s0960-9822(98)70239-8

PMID:9635180

Abstract

Nucleocytoplasmic transport involves assembly and movement across the nuclear envelope of cargo-receptor complexes that interact with the small GTPase Ran. The asymmetric distribution of Ran regulator proteins, RanGAP1 and RCC1, provides the driving force and directionality for nuclear transport.

摘要

核质运输涉及货物受体复合物与小GTP酶Ran相互作用并穿过核膜的组装和移动。Ran调节蛋白RanGAP1和RCC1的不对称分布为核运输提供了驱动力和方向性。