L-myc基因限制性片段长度多态性与胃癌易感性之间的关联。

Association between restriction fragment length polymorphism of the L-myc gene and susceptibility to gastric cancer.

作者信息

Shibuta K, Mori M, Haraguchi M, Yoshikawa K, Ueo H, Akiyoshi T

机构信息

Department of Surgery and Pathology, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan.

出版信息

Br J Surg. 1998 May;85(5):681-4. doi: 10.1046/j.1365-2168.1998.00638.x.

DOI:10.1046/j.1365-2168.1998.00638.x

PMID:9635822

Abstract

BACKGROUND

L-myc polymorphism has been documented to be a representative genetic trait which is related an individual's susceptibility to several cancers. However, there have been no reports concerning any significant association between susceptibility to gastric cancer and L-myc polymorphism.

METHODS

The distribution of L-myc polymorphism in 61 patients with gastric cancer was determined by polymerase chain reaction-based restriction fragment length polymorphism and compared with that of 107 healthy control subjects.

RESULTS

There was a significant difference in the distribution of both genotypes (P = 0.024) and allele frequencies (P = 0.026) between the two groups. The relative risk of gastric cancer for genotypes with the shorter (S) allele was 3.09 compared with the longer (L) allele homozygote. No significant correlation with clinicopathological features of the cancers except for prognosis was found. The patients with SS genotypes had a worse prognosis than those with LL or LS genotypes (P = 0.029).

CONCLUSION

L-myc polymorphism may be significant in an individual's susceptibility to gastric cancer in Japan, and may be a useful marker for identifying patients at high risk of developing gastric cancer.

摘要

背景

L-myc基因多态性已被证明是一种代表性的遗传特征，与个体对多种癌症的易感性相关。然而，尚无关于胃癌易感性与L-myc基因多态性之间存在任何显著关联的报道。

方法

采用基于聚合酶链反应的限制性片段长度多态性方法，测定61例胃癌患者中L-myc基因多态性的分布情况，并与107名健康对照者进行比较。

结果

两组之间的基因型分布（P = 0.024）和等位基因频率（P = 0.026）均存在显著差异。与较长（L）等位基因纯合子相比，具有较短（S）等位基因的基因型患胃癌的相对风险为3.09。除预后外，未发现与癌症的临床病理特征有显著相关性。SS基因型患者的预后比LL或LS基因型患者差（P = 0.029）。