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High-dose therapy including carboplatin adjusted for renal function in patients with relapsed or refractory germ cell tumour: outcome and prognostic factors.针对复发或难治性生殖细胞肿瘤患者，采用根据肾功能调整剂量的卡铂进行高剂量治疗：疗效及预后因素
Br J Cancer. 1998 May;77(10):1672-6. doi: 10.1038/bjc.1998.275.
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High-dose treatment with carboplatin, etoposide, and ifosfamide followed by autologous stem-cell transplantation in relapsed or refractory germ cell cancer: a phase I/II study. The German Testicular Cancer Cooperative Study Group.卡铂、依托泊苷和异环磷酰胺大剂量治疗后行自体干细胞移植治疗复发或难治性生殖细胞癌：一项I/II期研究。德国睾丸癌协作研究组。
J Clin Oncol. 1994 Jun;12(6):1223-31. doi: 10.1200/JCO.1994.12.6.1223.
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[Two cases of relapse or refractory germ cell tumor who had been treated with combination chemotherapy of cisplatin and carboplatin].
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Nephrotoxicity after high-dose carboplatin, etoposide and ifosfamide in germ-cell tumors: incidence and implications for hematologic recovery and clinical outcome.高剂量卡铂、依托泊苷和异环磷酰胺治疗生殖细胞肿瘤后的肾毒性：发生率及其对血液学恢复和临床结局的影响
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本文引用的文献

1
High-dose chemotherapy as salvage treatment in germ cell tumors: a multivariate analysis of prognostic variables.高剂量化疗作为生殖细胞肿瘤的挽救性治疗：预后变量的多因素分析
J Clin Oncol. 1996 Oct;14(10):2638-45. doi: 10.1200/JCO.1996.14.10.2638.
2
Treatment of germ cell cancer with two cycles of high-dose ifosfamide, carboplatin, and etoposide with autologous stem-cell support.采用两周期大剂量异环磷酰胺、卡铂和依托泊苷联合自体干细胞支持治疗生殖细胞癌。
J Clin Oncol. 1996 Oct;14(10):2631-7. doi: 10.1200/JCO.1996.14.10.2631.
3
High-dose chemotherapy and autologous bone marrow transplantation for patients with poor prognosis nonseminomatous germ cell tumours.高剂量化疗及自体骨髓移植用于预后不良的非精原细胞性生殖细胞肿瘤患者。
Br J Cancer. 1993 Sep;68(3):594-8. doi: 10.1038/bjc.1993.392.
4
Phase I trial with pharmacokinetic analyses of high-dose carboplatin, etoposide, and cyclophosphamide with autologous bone marrow transplantation in patients with refractory germ cell tumors.高剂量卡铂、依托泊苷和环磷酰胺联合自体骨髓移植治疗难治性生殖细胞肿瘤的Ⅰ期药代动力学分析试验。
Cancer Res. 1993 Aug 15;53(16):3730-5.
5
High-dose treatment with carboplatin, etoposide, and ifosfamide followed by autologous stem-cell transplantation in relapsed or refractory germ cell cancer: a phase I/II study. The German Testicular Cancer Cooperative Study Group.卡铂、依托泊苷和异环磷酰胺大剂量治疗后行自体干细胞移植治疗复发或难治性生殖细胞癌：一项I/II期研究。德国睾丸癌协作研究组。
J Clin Oncol. 1994 Jun;12(6):1223-31. doi: 10.1200/JCO.1994.12.6.1223.
6
Advanced seminoma: treatment results, survival, and prognostic factors in 142 patients.晚期精原细胞瘤：142例患者的治疗结果、生存率及预后因素
J Clin Oncol. 1994 Jan;12(1):120-6. doi: 10.1200/JCO.1994.12.1.120.
7
Carboplatin dosage: prospective evaluation of a simple formula based on renal function.卡铂剂量：基于肾功能的简单公式的前瞻性评估。
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Long-term outcome in patients with germ cell tumours treated with POMB/ACE chemotherapy: comparison of commonly used classification systems of good and poor prognosis.采用POMB/ACE化疗方案治疗的生殖细胞肿瘤患者的长期预后：常用的良好和不良预后分类系统比较
Br J Cancer. 1989 Feb;59(2):236-42. doi: 10.1038/bjc.1989.48.
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Salvage chemotherapy for patients with germ cell tumors. The Memorial Sloan-Kettering Cancer Center experience (1979-1989).生殖细胞肿瘤患者的挽救性化疗。纪念斯隆凯特琳癌症中心的经验（1979 - 1989年）
Cancer. 1991 Mar 1;67(5):1305-10. doi: 10.1002/1097-0142(19910301)67:5<1305::aid-cncr2820670506>3.0.co;2-j.
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High-dose chemotherapy supported with autologous bone marrow transplantation (ABMT) in germ cell tumors: a phase two study.
Ann Oncol. 1992 Dec;3(10):809-12. doi: 10.1093/oxfordjournals.annonc.a058100.

针对复发或难治性生殖细胞肿瘤患者，采用根据肾功能调整剂量的卡铂进行高剂量治疗：疗效及预后因素

High-dose therapy including carboplatin adjusted for renal function in patients with relapsed or refractory germ cell tumour: outcome and prognostic factors.

作者信息

Lyttelton M P, Newlands E S, Giles C, Bower M, Guimaraes A, O'Reilly S, Rustin G J, Samson D, Kanfer E J

机构信息

Department of Haematology, Imperial College School of Medicine, Hammersmith Hospitals NHS Trust, London, UK.

出版信息

Br J Cancer. 1998 May;77(10):1672-6. doi: 10.1038/bjc.1998.275.

DOI:10.1038/bjc.1998.275
PMID:9635847
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2150058/
Abstract

Thirty-one consecutive patients with relapsed or refractory GCT received an HDT schedule including carboplatin, the dose of which was adjusted to measured glomerular filtration rate. There was one HDT-associated death (3%), due to acute renal failure. The 3-year probability of overall and disease-free survival for 21 patients with primary refractory disease or responsive relapse was 60% and 42%, respectively, while none of ten patients with refractory relapse have survived disease free.

摘要

31例复发或难治性生殖细胞肿瘤（GCT）患者接受了含卡铂的高剂量化疗（HDT）方案，卡铂剂量根据测得的肾小球滤过率进行调整。发生1例HDT相关死亡（3%），死因是急性肾衰竭。21例原发性难治性疾病或反应性复发患者的3年总生存率和无病生存率分别为60%和42%，而10例难治性复发患者均无病生存。