Sukov W, Barth D S
Department of Psychology, University of Colorado, Boulder, Colorado 80309-0345, USA.
J Neurophysiol. 1998 Jun;79(6):2875-84. doi: 10.1152/jn.1998.79.6.2875.
The purpose of this study was to investigate interactions among laminar cell populations producing spontaneous and evoked high-frequency (approximately 40 Hz) gamma oscillations in auditory cortex. Electrocortical oscillations were recorded using a 64-channel epipial electrode array and a 16-channel linear laminar electrode array while electrical stimulation was delivered to the posterior intralaminar (PIL) nucleus. Spontaneous gamma oscillations, and those evoked by PIL stimulation, are confined to a location overlapping primary and secondary auditory cortex. Current source-density and principal components analysis of laminar recordings at this site indicate that the auditory evoked potential (AEP) complex is characterized by a stereotyped asynchronous activation of supra- and infragranular cell populations. Similar analysis of spontaneous and evoked gamma waves reveals a close spatiotemporal similarity to the laminar AEP, indicating rhythmic interactions between supra- and infragranular cell groups during these oscillatory phenomena. We conclude that neural circuit interactions producing the laminar AEP onset in auditory cortex are the same as those generating evoked and spontaneous gamma oscillations.
本研究的目的是调查在听觉皮层中产生自发和诱发高频（约40赫兹）伽马振荡的层状细胞群之间的相互作用。在将电刺激施加到丘脑后内侧核（PIL）时，使用64通道软脑膜电极阵列和16通道线性层状电极阵列记录皮层电图振荡。自发伽马振荡以及由PIL刺激诱发的伽马振荡局限于与初级和次级听觉皮层重叠的位置。该部位层状记录的电流源密度和主成分分析表明，听觉诱发电位（AEP）复合体的特征是颗粒上层和颗粒下层细胞群的刻板异步激活。对自发和诱发伽马波的类似分析揭示了与层状AEP在时空上的密切相似性，表明在这些振荡现象期间颗粒上层和颗粒下层细胞群之间存在节律性相互作用。我们得出结论，在听觉皮层中产生层状AEP起始的神经回路相互作用与产生诱发和自发伽马振荡的相互作用相同。
