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1
Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice.II型胶原蛋白中HLA - DR4限制性免疫显性表位的MHC与T细胞受体接触的定义以及HLA - DR4和人CD4转基因小鼠中胶原诱导性关节炎的特征
Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7574-9. doi: 10.1073/pnas.95.13.7574.
2
Analog peptides of type II collagen can suppress arthritis in HLA-DR4 (DRB1*0401) transgenic mice.II型胶原蛋白的模拟肽可抑制HLA-DR4（DRB1*0401）转基因小鼠的关节炎。
Arthritis Res Ther. 2006;8(5):R150. doi: 10.1186/ar2043.
3
HLA-DR1 (DRB1*0101) and DR4 (DRB1*0401) use the same anchor residues for binding an immunodominant peptide derived from human type II collagen.HLA-DR1（DRB1*0101）和DR4（DRB1*0401）利用相同的锚定残基来结合源自人II型胶原蛋白的免疫显性肽。
J Immunol. 2002 Jan 1;168(1):253-9. doi: 10.4049/jimmunol.168.1.253.
4
Collagen-induced arthritis mediated by HLA-DR1 (*0101) and HLA-DR4 (*0401).由HLA - DR1（*0101）和HLA - DR4（*0401）介导的胶原诱导性关节炎。
Am J Med Sci. 2004 Apr;327(4):169-79. doi: 10.1097/00000441-200404000-00002.
5
Interferon-gamma production in response to in vitro stimulation with collagen type II in rheumatoid arthritis is associated with HLA-DRB1(*)0401 and HLA-DQ8.类风湿关节炎患者中，对Ⅱ型胶原体外刺激产生的γ干扰素与HLA - DRB1（*）0401和HLA - DQ8相关。
Arthritis Res. 2000;2(1):75-84. doi: 10.1186/ar71.
6
Induction of autoimmune arthritis in HLA-DR4 (DRB1*0401) transgenic mice by immunization with human and bovine type II collagen.通过用人和牛II型胶原蛋白免疫在HLA - DR4（DRB1*0401）转基因小鼠中诱导自身免疫性关节炎。
J Immunol. 1998 Mar 15;160(6):2573-8.
7
Synthetic peptides that inhibit binding of the collagen type II 261-273 epitope to rheumatoid arthritis-associated HLA-DR1 and -DR4 molecules and collagen-specific T-cell responses.抑制II型胶原蛋白261 - 273表位与类风湿性关节炎相关的HLA - DR1和 - DR4分子结合以及胶原蛋白特异性T细胞反应的合成肽。
Hum Immunol. 2000 Jul;61(7):640-50. doi: 10.1016/s0198-8859(00)00126-9.
8
T cell responses to a human cartilage autoantigen in the context of rheumatoid arthritis-associated and nonassociated HLA-DR4 alleles.在类风湿性关节炎相关和非相关HLA - DR4等位基因背景下，T细胞对人软骨自身抗原的反应。
Arthritis Rheum. 1999 Jul;42(7):1497-507. doi: 10.1002/1529-0131(199907)42:7<1497::AID-ANR25>3.0.CO;2-#.
9
Complementation between HLA-DR4 (DRB1*0401) and specific H2-A molecule in transgenic mice leads to collagen-induced arthritis.转基因小鼠中HLA - DR4（DRB1*0401）与特定H2 - A分子之间的互补作用会导致胶原诱导的关节炎。
Hum Immunol. 1999 Sep;60(9):816-25. doi: 10.1016/s0198-8859(99)00070-1.
10
Use of soluble peptide-DR4 tetramers to detect synovial T cells specific for cartilage antigens in patients with rheumatoid arthritis.使用可溶性肽-DR4四聚体检测类风湿性关节炎患者中对软骨抗原有特异性的滑膜T细胞。
Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):291-6. doi: 10.1073/pnas.97.1.291.

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1
Human MHC Class II and Invariant Chain Knock-in Mice Mimic Rheumatoid Arthritis with Allele Restriction in Immune Response and Arthritis Association.人类 MHC II 类和不变链敲入小鼠模拟类风湿关节炎，具有免疫反应和关节炎相关性的等位基因限制。
Adv Sci (Weinh). 2024 Jun;11(23):e2401513. doi: 10.1002/advs.202401513. Epub 2024 Apr 11.
2
Transgenic Mice Expressing Functional TCRs Specific to Cardiac Myhc-α 334-352 on Both CD4 and CD8 T Cells Are Resistant to the Development of Myocarditis on C57BL/6 Genetic Background.转基因小鼠在 CD4 和 CD8 T 细胞上表达针对心肌肌球蛋白重链-α 334-352 的功能性 TCR，可抵抗 C57BL/6 遗传背景下心肌炎的发展。
Cells. 2023 Sep 25;12(19):2346. doi: 10.3390/cells12192346.
3
Significance of Type II Collagen Posttranslational Modifications: From Autoantigenesis to Improved Diagnosis and Treatment of Rheumatoid Arthritis.Ⅱ型胶原翻译后修饰的意义：从自身抗原性到改善类风湿关节炎的诊断和治疗。
Int J Mol Sci. 2023 Jun 8;24(12):9884. doi: 10.3390/ijms24129884.
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Therapy targeting antigen-specific T cells by a peptide-based tolerizing vaccine against autoimmune arthritis.针对自身免疫性关节炎的基于肽的耐受疫苗靶向抗原特异性 T 细胞的治疗。
Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2218668120. doi: 10.1073/pnas.2218668120. Epub 2023 Jun 12.
5
Molecular Mimicry of the Rheumatoid Arthritis-Related Immunodominant T-Cell Epitope within Type II Collagen (CII260-270) by the Bacterial L-Asparaginase.细菌 L-天冬酰胺酶对类风湿关节炎相关免疫显性 T 细胞表位（CII260-270 型 II 胶原内）的分子模拟。
Int J Mol Sci. 2022 Aug 15;23(16):9149. doi: 10.3390/ijms23169149.
6
Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor.由类风湿关节炎相关的 DRB1*04:01 分子、主要糖基化胶原 II 肽和 T 细胞受体组成的三聚体复合物中的关键相互作用。
Ann Rheum Dis. 2022 Apr;81(4):480-489. doi: 10.1136/annrheumdis-2021-220500. Epub 2022 Jan 13.
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Humanized Mouse Models of Rheumatoid Arthritis for Studies on Immunopathogenesis and Preclinical Testing of Cell-Based Therapies.类风湿关节炎的人源化小鼠模型用于免疫发病机制研究和基于细胞的疗法的临床前测试。
Front Immunol. 2019 Feb 19;10:203. doi: 10.3389/fimmu.2019.00203. eCollection 2019.
8
Complement in the Initiation and Evolution of Rheumatoid Arthritis.补体在类风湿关节炎的发生和演变中的作用。
Front Immunol. 2018 May 28;9:1057. doi: 10.3389/fimmu.2018.01057. eCollection 2018.
9
Targeting IgG in Arthritis: Disease Pathways and Therapeutic Avenues.靶向 IgG 治疗关节炎：疾病通路与治疗策略
Int J Mol Sci. 2018 Feb 28;19(3):677. doi: 10.3390/ijms19030677.
10
Use of Humanized Mice to Study the Pathogenesis of Autoimmune and Inflammatory Diseases.利用人源化小鼠研究自身免疫性疾病和炎症性疾病的发病机制。
Inflamm Bowel Dis. 2015 Jul;21(7):1652-73. doi: 10.1097/MIB.0000000000000446.

本文引用的文献

1
Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature. 1996. 384: 134-141.人类T细胞受体、病毒肽与HLA - A2之间复合物的结构。《自然》。1996年。第384卷：第134 - 141页。
J Immunol. 2010 Dec 1;185(11):6394-401.
2
Functional characterization of HLA-DRA1*0101/DRB1*0401 molecules expressed in Drosophila melanogaster cells.
Tissue Antigens. 1998 Feb;51(2):119-28.
3
The HLA-DQ7 and -DQ8 associations in DR4-positive rheumatoid arthritis patients. A combined analysis of data available in the literature.DR4阳性类风湿关节炎患者中HLA-DQ7和-DQ8的关联：文献中可用数据的综合分析
Tissue Antigens. 1997 Nov;50(5):494-500. doi: 10.1111/j.1399-0039.1997.tb02905.x.
4
X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II.与来自人胶原蛋白II的肽复合的HLA - DR4（DRA*0101，DRB1*0401）的X射线晶体结构。
Immunity. 1997 Oct;7(4):473-81. doi: 10.1016/s1074-7613(00)80369-6.
5
A mechanism for the major histocompatibility complex-linked resistance to autoimmunity.一种与主要组织相容性复合体相关的自身免疫抗性机制。
J Exp Med. 1997 Oct 6;186(7):1059-75. doi: 10.1084/jem.186.7.1059.
6
Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha1*0101,beta1*0401) transgenic mice.利用HLA-DR（α1*0101，β1*0401）转基因小鼠鉴定人谷氨酸脱羧酶65的免疫显性T细胞表位。
Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8082-7. doi: 10.1073/pnas.94.15.8082.
7
An HLA-DR1 transgene confers susceptibility to collagen-induced arthritis elicited with human type II collagen.HLA - DR1转基因使人对由人II型胶原蛋白引发的胶原诱导性关节炎易感。
J Exp Med. 1997 Mar 17;185(6):1113-22. doi: 10.1084/jem.185.6.1113.
8
Antibodies to type II collagen in early rheumatoid arthritis. Correlation with disease progression.早期类风湿关节炎中抗II型胶原蛋白抗体。与疾病进展的相关性。
Arthritis Rheum. 1996 Oct;39(10):1720-7. doi: 10.1002/art.1780391015.
9
Immune response of HLA-DQ8 transgenic mice to peptides from the third hypervariable region of HLA-DRB1 correlates with predisposition to rheumatoid arthritis.HLA-DQ8转基因小鼠对HLA-DRB1第三个高变区肽段的免疫反应与类风湿关节炎易感性相关。
Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):1814-9. doi: 10.1073/pnas.93.5.1814.
10
Specificity of an HLA-DRB1*0401-restricted T cell response to type II collagen.对II型胶原蛋白的HLA-DRB1*0401限制性T细胞反应的特异性
Eur J Immunol. 1996 Apr;26(4):928-33. doi: 10.1002/eji.1830260431.

II型胶原蛋白中HLA - DR4限制性免疫显性表位的MHC与T细胞受体接触的定义以及HLA - DR4和人CD4转基因小鼠中胶原诱导性关节炎的特征

Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice.

作者信息

Andersson E C, Hansen B E, Jacobsen H, Madsen L S, Andersen C B, Engberg J, Rothbard J B, McDevitt G S, Malmström V, Holmdahl R, Svejgaard A, Fugger L

机构信息

Departments of Clinical Immunology, Rigshospitalet, 2200 N Copenhagen, Denmark.

出版信息

Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7574-9. doi: 10.1073/pnas.95.13.7574.

DOI:10.1073/pnas.95.13.7574
PMID:9636191
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC22687/
Abstract

Rheumatoid arthritis (RA) is an autoimmune disease associated with the HLA-DR4 and DR1 alleles. The target autoantigen(s) in RA is unknown, but type II collagen (CII) is a candidate, and the DR4- and DR1-restricted immunodominant T cell epitope in this protein corresponds to amino acids 261-273 (CII 261-273). We have defined MHC and T cell receptor contacts in CII 261-273 and provide strong evidence that this peptide corresponds to the peptide binding specificity previously found for RA-associated DR molecules. Moreover, we demonstrate that HLA-DR4 and human CD4 transgenic mice homozygous for the I-Abbeta0 mutation are highly susceptible to collagen-induced arthritis and describe the clinical course and histopathological changes in the affected joints.

摘要

类风湿性关节炎（RA）是一种与HLA - DR4和DR1等位基因相关的自身免疫性疾病。RA中的靶自身抗原尚不清楚，但II型胶原（CII）是一个候选抗原，该蛋白中受DR4和DR1限制的免疫显性T细胞表位对应于氨基酸261 - 273（CII 261 - 273）。我们已经确定了CII 261 - 273中MHC和T细胞受体的接触点，并提供了强有力的证据表明该肽段与先前发现的与RA相关的DR分子的肽结合特异性相对应。此外，我们证明了纯合I - Abeta0突变的HLA - DR4和人类CD4转基因小鼠对胶原诱导的关节炎高度易感，并描述了受影响关节的临床病程和组织病理学变化。