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Blockade of alpha 4 beta 1-integrin-fibronectin adhesive interactions prevents chronic allograft rejection in sensitized recipients.

作者信息

Coito A J, Korom S, Hancock W W, Kupiec-Weglinski J W

机构信息

Department of Surgery, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

出版信息

Transplant Proc. 1998 Jun;30(4):939-40. doi: 10.1016/s0041-1345(98)00099-2.

DOI:10.1016/s0041-1345(98)00099-2
PMID:9636377
Abstract
摘要

相似文献

1
Blockade of alpha 4 beta 1-integrin-fibronectin adhesive interactions prevents chronic allograft rejection in sensitized recipients.阻断α4β1整合素与纤连蛋白的黏附相互作用可预防致敏受者的慢性同种异体移植排斥反应。
Transplant Proc. 1998 Jun;30(4):939-40. doi: 10.1016/s0041-1345(98)00099-2.
2
Distinct fibronectin splicing variants: potential targets for therapeutic immunomodulation in organ allograft recipients.独特的纤连蛋白剪接变体:器官移植受者治疗性免疫调节的潜在靶点。
Transplant Proc. 1997 Feb-Mar;29(1-2):1060-1. doi: 10.1016/s0041-1345(96)00382-x.
3
Blockade of very late antigen-4 integrin binding to fibronectin in allograft recipients. II. Treatment with connecting segment-1 peptides prevents chronic rejection by attenuating arteriosclerotic development and suppressing intragraft T cell and macrophage activation.同种异体移植受者中晚期抗原-4整合素与纤连蛋白结合的阻断。II. 用连接段-1肽治疗可通过减轻动脉粥样硬化发展和抑制移植内T细胞及巨噬细胞活化来预防慢性排斥反应。
Transplantation. 1998 Mar 27;65(6):854-9. doi: 10.1097/00007890-199803270-00014.
4
Blockade of very late antigen-4 integrin binding to fibronectin in allograft recipients: I. Treatment with connecting segment-1 peptides prevents acute rejection by suppressing intragraft mononuclear cell accumulation, endothelial activation, and cytokine expression.同种异体移植受者中晚期抗原-4整合素与纤连蛋白结合的阻断:I. 用连接段-1肽治疗可通过抑制移植体内单核细胞积聚、内皮细胞活化和细胞因子表达来预防急性排斥反应。
Transplantation. 1998 Mar 15;65(5):699-706. doi: 10.1097/00007890-199803150-00017.
5
Anti-integrin (LFA-1, VLA-4, and Mac-1) antibody treatment and acute cardiac graft rejection in the rat.
Transpl Int. 1996;9(4):420-5. doi: 10.1007/BF00335706.
6
Anti-VLA-4 and cyclosporine synergistically prolong rat heterotopic small bowel allografts.抗VLA-4与环孢素协同作用可延长大鼠异位小肠同种异体移植的存活时间。
Transplant Proc. 1996 Oct;28(5):2496.
7
Effect of monoclonal antibody to VLA-4 on corneal allograft survival in mice.抗VLA-4单克隆抗体对小鼠角膜移植存活的影响。
Transplant Proc. 1996 Jun;28(3):1990-1.
8
Immunosuppression by blocking alpha 4-integrins/VCAM-1 adhesion.通过阻断α4整合素/血管细胞黏附分子-1黏附实现免疫抑制。
Curr Top Microbiol Immunol. 1998;231:85-98. doi: 10.1007/978-3-642-71987-5_6.
9
Rapamycin abrogates accelerated rejection in sensitized rats by selectively suppressing intragraft cell activation, adhesion/binding properties, and modulating serum alloantibody responses.
Transplant Proc. 1995 Feb;27(1):427-9.
10
Mycophenolate mofetil's effect on accelerated heart allograft rejection and rejection markers in the rat.霉酚酸酯对大鼠心脏移植加速性排斥反应及排斥反应标志物的影响。
Transplant Proc. 1998 Jun;30(4):1049-50. doi: 10.1016/s0041-1345(98)00146-8.

引用本文的文献

1
Genomic meta-analysis of growth factor and integrin pathways in chronic kidney transplant injury.生长因子和整合素通路的全基因组荟萃分析在慢性肾移植损伤中的作用。
BMC Genomics. 2013 Apr 23;14:275. doi: 10.1186/1471-2164-14-275.
2
Discordant effects of anti-VLA-4 treatment before and after onset of relapsing experimental autoimmune encephalomyelitis.复发性实验性自身免疫性脑脊髓炎发作前后抗VLA - 4治疗的不一致效应
J Clin Invest. 2001 Apr;107(8):995-1006. doi: 10.1172/JCI11717.
3
Fibronectin-mononuclear cell interactions regulate type 1 helper T cell cytokine network in tolerant transplant recipients.
纤连蛋白-单核细胞相互作用调节移植耐受受者的1型辅助性T细胞细胞因子网络。
Am J Pathol. 2000 Oct;157(4):1207-18. doi: 10.1016/S0002-9440(10)64636-6.