Billon C, Beylot-Barry M, Doutre M S, Latapie J L, Roger P, Beylot C
Service de Dermatologie, Hôpital du Haul-Lévêque, Pessac.
Ann Dermatol Venereol. 1996;123(12):821-3.
Some skin changes in acromegaly belong to the classical dysmorphic syndrome. Furthermore, other minor skin changes can be associated.
We report 3 patients consulting in the department of Dermatology for various skin changes that have lead to the diagnosis of acromegaly. However these patients have also typical dysmorphic syndrome that they have failed to recognize. The fourth patient associated a cutaneous mastocytosis and acromegaly, as reported only once in literature. The evolution of the minor skin changes was parallel with the endocrinopathy. Moreover in one case, they have preceded the recurrence of the acromegaly.
Our observations demonstrate the importance of the minor skin changes that lead the patient to consult more than the dysmorphic syndrome. Moreover these changes that depend of growth hormone and other associated growth factors can be evolutive signs for endocrinopathy.
肢端肥大症的一些皮肤改变属于典型的畸形综合征。此外，还可能伴有其他轻微的皮肤改变。
我们报告了3例因各种皮肤改变而到皮肤科就诊的患者，这些皮肤改变最终导致了肢端肥大症的诊断。然而，这些患者还存在典型的畸形综合征，但他们自己并未意识到。第四例患者同时患有皮肤肥大细胞增多症和肢端肥大症，这种情况在文献中仅被报道过一次。轻微皮肤改变的演变与内分泌病平行。此外，在一个病例中，这些改变先于肢端肥大症的复发出现。
我们的观察结果表明，导致患者前来就诊的轻微皮肤改变比畸形综合征更为重要。此外，这些依赖生长激素和其他相关生长因子的改变可能是内分泌病的演变迹象。
