Okuma Y, Shimo Y, Shimura H, Hatori K, Hattori T, Tanaka S, Kondo T, Mizuno Y
Department of Neurology, Juntendo University School of Medicine, Bunkyo, Tokyo, Japan.
Clin Neurol Neurosurg. 1998 Mar;100(1):75-8. doi: 10.1016/s0303-8467(98)00003-1.
The authors report three Japanese families presenting with cortical tremor and epilepsy. The patients showed either tremulous finger movements or seizures as the initial symptoms between 19 and 30 years of the age without progression. Postural tremor resembled essential tremor and responded to the anticonvulsants such as clonazepam, primidone and sodium valproate. Seizures were infrequent. These patients seem to have the same disorder as what the authors have described as 'familial cortical tremor with epilepsy'. Familial cortical tremor must be more common than previously thought and should be taken into consideration in the patients with 'familial essential tremor' who do not respond well to beta-blockers.
作者报告了三个表现为皮质震颤和癫痫的日本家庭。患者在19至30岁之间以手指震颤运动或癫痫发作为初始症状，且无病情进展。姿势性震颤类似于特发性震颤，对氯硝西泮、扑米酮和丙戊酸钠等抗惊厥药有反应。癫痫发作不频繁。这些患者似乎患有与作者所描述的“家族性皮质震颤伴癫痫”相同的疾病。家族性皮质震颤肯定比以前认为的更为常见，对于对β受体阻滞剂反应不佳的“家族性特发性震颤”患者应予以考虑。
