Kumita S, Kumazaki T, Cho K, Mizumura S, Kijima T, Ishihara M, Nakajo H, Sano J, Tada Y, Sakai S, Kusama Y, Munakata K
Department of Radiology, Nippon Medical School, Tokyo, Japan.
Ann Nucl Med. 1998 Apr;12(2):71-5. doi: 10.1007/BF03164832.
Into 25 patients with heart disorders, 99mTc-tetrofosmin 555-740 MBq was injected intravenously at rest. After 40 minutes, ECG-gated myocardial perfusion SPECT was performed with a two detector gamma camera VERTEX (ADAC), setting up two detectors to form a 90-degree angle. Sixteen frames per R-R interval were acquired during a 180 degree rotation from the RAO 45 degrees to the LPO 45 degrees. A pair of data sets with standard (SDA) and rapid data acquisition (RDA) protocols was collected. In an SDA protocol, SPECT imaging was performed for 50 sec per step in 5 degree angular steps (total acquisition time; 15 minutes). An RDA protocol was conducted with 12 sec per step, 6 degree angular steps (acquisition time, 3 minutes). LVEF (%) and LVEDV (ml) quantitated automatically with a QGS program showed excellent correlations between two protocols with correlation coefficients of 0.980 (p < 0.01) and 0.983 (p < 0.01), respectively. Subsequently visual assessment of regional wall motion based on a four-point grading system was carried out with a 3-D cine LV display. High complete agreement was gained with 158 (90.3%) out of total 175 segments, so that assessment of the global and regional LV function with the RDA protocol demonstrated high reliability and feasibility.
对25例心脏病患者，静息状态下经静脉注射555 - 740MBq的99mTc - 替曲膦。40分钟后，使用双探头γ相机VERTEX（ADAC）进行心电图门控心肌灌注单光子发射计算机断层显像（SPECT），将两个探头设置成90度角。在从右前斜45度到左后斜45度的180度旋转过程中，每个R - R间期采集16帧图像。收集了一组采用标准数据采集（SDA）协议和快速数据采集（RDA）协议的数据集。在SDA协议中，以5度角步长每步进行50秒的SPECT成像（总采集时间为15分钟）。RDA协议以6度角步长每步进行12秒的成像（采集时间为3分钟）。用QGS程序自动定量测定的左心室射血分数（LVEF，%）和左心室舒张末期容积（LVEDV，ml）显示两种协议之间具有良好的相关性，相关系数分别为0.980（p < 0.01）和0.983（p < 0.01）。随后，基于四点分级系统，通过三维左心室电影显示对室壁运动进行视觉评估。在总共175个节段中，158个节段（90.3%）获得了高度完全一致的结果，因此用RDA协议评估左心室整体和局部功能具有高度的可靠性和可行性。
