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急性心肌梗死患者无抗凝情况下的微支架植入:两种不同抗栓方案的临床经验

Micro stent implantation in patients with acute myocardial infarction without anticoagulation: clinical experience with two different antithrombotic protocols.

作者信息

Oemrawsingh P V, Schalij M J, Udayachalerm W, van der Wall E E, Bruschke A V

机构信息

Department of Cardiology, Leiden University Hospital, The Netherlands.

出版信息

Cathet Cardiovasc Diagn. 1998 Jun;44(2):131-7. doi: 10.1002/(sici)1097-0304(199806)44:2<131::aid-ccd1>3.0.co;2-7.

Abstract

The 4-week outcome following Micro stent implantation for acute myocardial infarction was assessed with the use of two different antithrombotic regimens. The patients were postprocedurally treated with acetyl salicylic acid (ASA) and heparin for 24-48 h (Group I; n = 52), or ASA and ticlopidine plus abciximab if indicated (Group II; n = 52). Stent implantation was successful in 49 patients (94%) of group I and in 46 patients (89%) of group II (NS). Subacute stent thrombosis occurred in nine patients (17%) of group I and in 1 patient (2%) of group II (P < 0.05). There were no significant differences in the rates of mortality, coronary bypass operation, or vascular complications. Micro stent implantation in acute myocardial infarction is highly effective and associated with a low risk for subacute stent thrombosis if the patients are postprocedurally treated with ASA and ticlopidine plus abciximab if indicated.

摘要

采用两种不同的抗血栓治疗方案评估了急性心肌梗死患者植入微型支架后的4周结果。术后患者接受乙酰水杨酸(ASA)和肝素治疗24 - 48小时(I组;n = 52),或根据情况接受ASA、噻氯匹定加阿昔单抗治疗(II组;n = 52)。I组49例患者(94%)和II组46例患者(89%)支架植入成功(无显著性差异)。I组9例患者(17%)发生亚急性支架血栓形成,II组1例患者(2%)发生亚急性支架血栓形成(P < 0.05)。死亡率、冠状动脉搭桥手术率或血管并发症发生率无显著差异。如果术后根据情况对患者采用ASA、噻氯匹定加阿昔单抗治疗,急性心肌梗死患者植入微型支架非常有效且亚急性支架血栓形成风险较低。

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