Pamnani M B, Simon G, Overbeck H W
Circ Res. 1976 Oct;39(4):517-23. doi: 10.1161/01.res.39.4.517.
We used the gracilis muscle vascular bed to bioassay blood from the two renal veins, vena cava, and aorta continuously for the presence of vasoactive agents before and for 45 minutes after partial occlusion of the left renal artery in dogs. Compared to comparable blood samples from control dogs, left renal venous, vena caval, and aortic blood, but not right renal venous blood, from dogs with renal artery constriction developed vasoconstrictor activity. This was associated with increased renin concentration in plasma from the left renal vein and the vena cava and an increase in systemic arterial pressure. In dogs pretreated with indomethacin, blood from the right renal vein also showed vasoconstrictor activity. Pretreatment with antirenin serum abolished all of the differences between control and experimental dogs. These findings suggest that during acute unilateral renal artery constriction the constricted kidney releases renin and the contralateral kidney releases prostaglandins in sufficient quantity to produce systemic vascular effects.
我们利用股薄肌血管床对狗左肾动脉部分闭塞前及闭塞后45分钟内来自两条肾静脉、腔静脉和主动脉的血液进行连续生物测定，以检测血管活性物质的存在。与对照犬的相应血样相比，肾动脉狭窄犬的左肾静脉血、腔静脉血和主动脉血（而非右肾静脉血）出现了血管收缩活性。这与左肾静脉和腔静脉血浆中肾素浓度升高以及体动脉压升高有关。在用吲哚美辛预处理的犬中，右肾静脉血也表现出血管收缩活性。用抗肾素血清预处理消除了对照犬和实验犬之间的所有差异。这些发现表明，在急性单侧肾动脉狭窄期间，狭窄侧肾脏释放肾素，对侧肾脏释放足够量的前列腺素以产生全身血管效应。
