Gauthier I, Malone M
Faculty of Pharmacy, University of Montreal Hospital Center, Quebec, Canada.
Drug Saf. 1998 Jun;18(6):383-93. doi: 10.2165/00002018-199818060-00001.
Drug-food interactions in hospitalised patients may result in decreased drug efficacy or increased drug toxicity. The increasing complexity of drug therapy regimens has increased the potential for drug-food interactions to occur, reinforcing the need to develop methods to prevent clinically significant drug-food interactions. Before selecting the optimal method, in terms of feasibility of implementation and successful outcome, drugs with the potential for clinically significant interactions with food must be identified. From an analysis of the literature, 6 methods to prevent drug-food interactions have been suggested as useful tools. Each method has its own advantages and disadvantages. Most have been developed in response to guidelines from the most well recognised agency for quality review in the US, the Joint Commission on Accreditation of Healthcare Organisations (JCAHO). Based on those recommendations, an ideal programme to prevent drug-food interactions would be a combined patient counselling and label system to select the most appropriate drug administration times and increase nurse and patient awareness of the potential for drug-food interactions. However, because of time constraints and limited resources, a label system or the provision of a drug-food interaction pamphlet to the patient before discharge would be a more practical method. Newsletters and educational in-services combined with patient counselling or a label system would be a valuable method to prevent drug-food interactions in hospitalised patients.
住院患者的药物与食物相互作用可能导致药物疗效降低或药物毒性增加。药物治疗方案日益复杂，增加了药物与食物相互作用发生的可能性，这进一步凸显了开发预防具有临床意义的药物与食物相互作用方法的必要性。在选择最佳方法时，就实施的可行性和成功结果而言，必须识别出可能与食物发生具有临床意义相互作用的药物。通过对文献的分析，已提出6种预防药物与食物相互作用的方法作为有用的工具。每种方法都有其自身的优缺点。大多数方法是根据美国最著名的质量审查机构医疗保健组织认证联合委员会（JCAHO）的指南开发的。基于这些建议，预防药物与食物相互作用的理想方案将是一个结合患者咨询和标签系统，以选择最合适的给药时间，并提高护士和患者对药物与食物相互作用可能性的认识。然而，由于时间限制和资源有限，出院前为患者提供标签系统或药物与食物相互作用宣传册将是一种更实用的方法。时事通讯和在职教育与患者咨询或标签系统相结合，将是预防住院患者药物与食物相互作用的一种有价值的方法。
