Yilmaz N, Ozkan S A, Uslu B, Sentürk Z, Biryol I
Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Turkey.
J Pharm Biomed Anal. 1998 Jun;17(2):349-55. doi: 10.1016/s0731-7085(97)00226-4.
A voltammetric study of the oxidation of terbutaline has been carried out at an activated glassy carbon electrode. The compound was oxidized irreversibly at high positive potential. The response was evaluated with respect to pH, scan rate, nature of the buffer and other variables. The peak current, at about 0.8 V (versus a saturated calomel electrode), was proportional to the terbutaline concentration in the range of 8 x 10(-6)-8 x 10(-4) M in phosphate buffer pH 6.0. This method was applied, without any interferences from the excipients, to determine the drug in a tablet dosage form.
已在活化玻碳电极上对特布他林的氧化进行了伏安法研究。该化合物在高正电位下发生不可逆氧化。针对pH值、扫描速率、缓冲液性质及其他变量对响应进行了评估。在pH 6.0的磷酸盐缓冲液中，约0.8 V（相对于饱和甘汞电极）处的峰电流与特布他林浓度在8×10⁻⁶ - 8×10⁻⁴ M范围内成正比。该方法用于测定片剂剂型中的药物，且不受辅料干扰。
