脑萎缩中的溶酶体酶

Lysosomal enzymes in cerebral atrophy.

作者信息

Yates C M, Urquhart A, Wilson H, Davidson D, Copland W A

出版信息

Clin Chim Acta. 1976 Sep 6;71(2):215-9. doi: 10.1016/0009-8981(76)90533-7.

Abstract

In seven patients with cerebral atrophy due to pre-senile dementia and/or cerebrovascular disease, the activity of acid phosphatase in lumbar cerebrospinal fluid (CSF) was higher (p less than 0.05) than in six controls. The activity of arylsulphatase and beta-galactosidase in CSF was the same in the two groups. In the serum, the activities of acid phosphatase and arylsulphatase were the same in the two groups but the activity of beta-galactosidase was lower (p less than 0.02) in patients with cerebral atrophy.

摘要

在7例因早老性痴呆和/或脑血管疾病导致脑萎缩的患者中，腰段脑脊液（CSF）中酸性磷酸酶的活性高于6例对照者（p<0.05）。两组CSF中芳基硫酸酯酶和β-半乳糖苷酶的活性相同。在血清中，两组酸性磷酸酶和芳基硫酸酯酶的活性相同，但脑萎缩患者的β-半乳糖苷酶活性较低（p<0.02）。