Carballada R, Esponda P
Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.
Int J Androl. 1998 Feb;21(1):19-28. doi: 10.1046/j.1365-2605.1998.00082.x.
The association of seminal vesicle (SV) proteins with rat spermatozoa has been studied in vivo and in vitro. SV proteins bind to the sperm plasma membrane after ejaculation but are removed progressively from the sperm plasma membrane in the female genital tract. Although some of these remain bound to spermatozoa when they reach the oviducts, they do not seem to be present at the time of fertilization. This could indicate a putative role for these SV proteins in pre-fertilization events. In addition, the binding of SV antigens was studied in vitro. It was observed that the ability to bind SV proteins is gained by the spermatozoa during epididymal maturation, and is first detectable in spermatozoa collected from the cauda epididymis. On the other hand, the binding is regulated by other proteins present in the ejaculate which are secreted by the coagulating glands. Experiments also showed that mouse spermatozoa are able to bind rat SV proteins, indicating that the binding is not a highly species-specific phenomenon.
已在体内和体外研究了精囊（SV）蛋白与大鼠精子的关联。射精后，SV蛋白与精子质膜结合，但在雌性生殖道中会逐渐从精子质膜上脱落。尽管其中一些在精子到达输卵管时仍与精子结合，但在受精时似乎并不存在。这可能表明这些SV蛋白在受精前事件中具有假定作用。此外，还在体外研究了SV抗原的结合情况。观察到精子在附睾成熟过程中获得了结合SV蛋白的能力，并且首先在从附睾尾部收集的精子中可检测到。另一方面，这种结合受射精中存在的其他由凝固腺分泌的蛋白质调节。实验还表明，小鼠精子能够结合大鼠SV蛋白，这表明这种结合不是高度物种特异性的现象。
