Bucinskaite V, Brodda-Jansen G, Stenfors C, Theodorsson E, Lundeberg T
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Neuropeptides. 1998 Apr;32(2):179-83. doi: 10.1016/s0143-4179(98)90035-x.
The effects of experimentally induced ischaemia after free-flap surgery on concentrations of neuropeptide Y (NPY), neurokinin A (NKA), substance P (SP) and calcitonin gene-related peptide (CGRP)-like immunoreactivity (-LI) were studied in flap tissue and in different regions of the rat brain (striatum, hippocampus, pituitary, hypothalamus, frontal and occipital cortex). Ten days after the operation, CGRP-LI and NKA-LI were decreased in the ischaemic tissue but increased in the surrounding tissue. In the brain, CGRP-LI was increased in five of six regions analysed, with the exception of the striatum. SP-LI and NKA-LI were increased in the pituitary and hippocampus, but decreased in other brain regions. Changes of CGRP-LI in the brain correlated positively with the CGRP-LI concentrations in the surrounding flap tissue and the CGRP-LI concentrations in the ischaemic flap tissue with the extent of flap survival. The results of the present study suggest that higher concentrations of CGRP-LI are related to tissue survival and that endogenous CGRP has a regulatory effect in ischaemia.
研究了游离皮瓣手术后实验性诱导缺血对皮瓣组织以及大鼠脑不同区域（纹状体、海马体、垂体、下丘脑、额叶和枕叶皮质）中神经肽Y（NPY）、神经激肽A（NKA）、P物质（SP）和降钙素基因相关肽（CGRP）样免疫反应性（-LI）浓度的影响。术后10天，缺血组织中的CGRP-LI和NKA-LI降低，但周围组织中的则升高。在脑中，分析的六个区域中有五个区域的CGRP-LI升高，纹状体除外。SP-LI和NKA-LI在垂体和海马体中升高，但在其他脑区域中降低。脑中CGRP-LI的变化与周围皮瓣组织中的CGRP-LI浓度以及缺血皮瓣组织中的CGRP-LI浓度与皮瓣存活程度呈正相关。本研究结果表明，较高浓度的CGRP-LI与组织存活有关，并且内源性CGRP在缺血中具有调节作用。
