Pauwels E K, Ribeiro M J, Stoot J H, McCready V R, Bourguignon M, Mazière B
Leiden University Medical Centre, Department of Radiology, The Netherlands.
Nucl Med Biol. 1998 May;25(4):317-22. doi: 10.1016/s0969-8051(97)00226-6.
The tumoral uptake of fluorine-18-deoxyglucose (FDG) is based upon enhanced glycolysis. Following injection, FDG is phosphorylated and trapped intracellularly. An important mechanism to transport FDG into the transformed cell is based upon the action of glucose transporter proteins; furthermore, highly active hexokinase bound to tumor mitochondria helps to trap FDG into the cell. In addition, enhanced FDG uptake may be due to relative hypoxia in tumor masses, which activates the anaerobic glycolytic pathway. In spite of these processes, FDG uptake is relatively aspecific since all living cells need glucose. Clinical use is therefore recommended in carefully selected patients.
氟-18-脱氧葡萄糖（FDG）的肿瘤摄取基于糖酵解增强。注射后，FDG被磷酸化并被困在细胞内。将FDG转运到转化细胞中的一个重要机制基于葡萄糖转运蛋白的作用；此外，与肿瘤线粒体结合的高活性己糖激酶有助于将FDG捕获到细胞中。此外，FDG摄取增加可能是由于肿瘤块中的相对缺氧，这激活了无氧糖酵解途径。尽管有这些过程，但由于所有活细胞都需要葡萄糖，FDG摄取相对缺乏特异性。因此，建议在精心挑选的患者中使用。
