Smith T A
Department of Nuclear Medicine, Royal Marsden NHS Trust, Sutton, Surrey, UK.
Nucl Med Commun. 1998 Feb;19(2):97-105. doi: 10.1097/00006231-199802000-00002.
The use of FDG-PET imaging in tumour detection is now well established. Many studies have suggested that changes in the uptake of FDG predict tumour response to therapy and that further clinical information regarding tumour grade and proliferative status may also be derived from FDG-uptake scans. More studies are required to verify the role of FDG-PET in patient management. Upregulation of hexokinase and glucose transporters, especially Glut-1, and downregulation of glucose-6-phosphatase are frequently associated with transformation. The extent of these changes has been related to both differentiation and proliferation largely corresponding with FDG-uptake studies.
氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）成像在肿瘤检测中的应用现已得到充分确立。许多研究表明，FDG摄取的变化可预测肿瘤对治疗的反应，而且有关肿瘤分级和增殖状态的更多临床信息也可从FDG摄取扫描中获得。需要更多研究来验证FDG-PET在患者管理中的作用。己糖激酶和葡萄糖转运蛋白，尤其是葡萄糖转运蛋白1（Glut-1）的上调以及葡萄糖-6-磷酸酶的下调常与肿瘤转化相关。这些变化的程度与分化和增殖均有关，在很大程度上与FDG摄取研究结果相符。
